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In a different study, the authors documented an anti-proliferative and apoptotic effect of GEN and the sensitivity to fluorouracil, using a canonical SMMC-7721 cell line

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Pflgers Arch Eur J Physiol

Interestingly, p53 3KR , an acetylation-defective mutant form of p53 (K117R, K161R, and K162R), effectively suppressed the expression of SLC7A11 but not other target genes of p53 [119]