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HPV vectors can be subjected to iterative cycles of reassembly (&/or one or more additional directed evolution methods described herein) and screening with a view to obtaining vectors with improved properties

Ann Clin Transl Neurol 8(10):19919 Wen J, Li S, Zheng C, Wang F, Luo Y, Wu L et al (2021) Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1/Nrf2/HO-1 pathway in ALS mice