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The three-amino-acid truncation transforms IGF-1 from a highly regulated, IGFBP-bound mediator into a potent, locally-acting growth factor with minimal systemic distribution

Planta Med 2001;67:3915

A Yale-led randomized placebo-controlled trial in 2009 tested it specifically for fibromyalgia: both the treatment group and the placebo group improved, which suggests a strong placebo or volume-expansion effect on top of any direct nutrient benefit

Luteolin downregulates IL-1-induced MMP-9 and-13 expressions in osteoblasts via inhibition of ERK signalling pathway

21 Three clinical trials, one open-label and uncontrolled, 22 one open-label and placebo controlled, 23 and one double-blind and placebo controlled, 24 investigated a multi-nutrient formulation containing NAC 1200 mg per day (other nutrients: folate, vitamin B12, alpha-tocopherol, S-adenosyl methionine and acetyl-L-carnitine) for 312 months in patients with Alzheimers disease, and found significant benefits in Dementia Rating Scale and clock-drawing tests as well as in assessments by caregivers in those receiving the multi-nutrient supplement versus placebo or versus baseline

Annals of Medicine, 56 (1), 2389469