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Regularly evaluate for adverse events such as respiratory depression, sedation, and hypotension [see CLINICAL PHARMACOLOGY]

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When iron homeostasis is perturbed, excess Fe 2+ catalyzes Fenton chemistry to produce highly reactive hydroxyl radicals (OH), triggering lipid peroxidation and cellular injury

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When administered under proper medical supervision with appropriate dosing protocols, ipamorelin is generally considered safe and well-tolerated for long-term use