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J Pharmacol Exp Ther (2011) 339:3544.10.1124/jpet.111.182220 134 KawasLHYamamotoBJWrightJWHardingJW

Proceed with caution if the peptide appears normal but has exceeded expected storage duration

Despite its central role in cancer biology, KRAS has long been considered undruggable due to its high affinity for GTP and the lack of suitable binding pockets for conventional inhibitors 6,7

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EXAMPLE 12: EFFECT OF DIFFERENT TONICITY AGENTS ON SUBCUTANEOUS TOLERANCE UPON SUBCUTANEOUS INJECTION This example shows the effect on local tolerance of any one of three different tonicity agents (sorbitol, mannitol and trehalose) in otherwise identical isotonic co-formulation vehicles

(Neuro Endocrinology Letters, 2003) reported that Epithalon stimulated telomerase activity in human somatic cells, resulting in measurable telomere elongation in vitro