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This was because the drug did not significantly reduce weight in 536 subjects over the course of 24 weeks 2

It is most often based on the clinical symptoms together with laboratory assessment (low serum vitamin B 12 level and elevated serum homocysteine or methylmalonic acid level) and the response to treatment to make definitive diagnosis

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If history or physical signs suggest dehydration, Reclast therapy should be withheld until normovolemic status has been achieved [see Adverse Reactions (6.2)]

"Oral supplemental interventions for the management of recurrent aphthous stomatitis (RAS) A systematic review and meta-analysis"