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Later, pharmacological studies also suggested that TRPM7 mediates apoptotic neuronal death caused by brain ischemia through modulation of CaMKII, calmodulin, and calcineurin (Turlova et al., 2021)

Curcumin has been shown to re-polarize these M2-like macrophages towards an M1-like phenotype, which is associated with anti-tumor activity and pro-inflammatory cytokine production

Oxidative stress is also reported to cause mitochondrial dysfunction which further leads to produce psychotic symptoms especially negative and cognitive symptoms

Examples include high-dose vitamin A or retinoids (which can be hepatotoxic in excess), green tea extract catechins (associated with rare cases of liver injury), kava, or high-dose niacin

Endocr Metab Immune Disord Drug Targets [Internet]