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131 In colorectal cancer, IKK induces the cytokine leukemia inhibitory factor (LIF) by inducing NF-B dependent transcriptional activity, thereby activating STAT3

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For example, under sustained heat stress, HSP70 levels increase more significantly than those of other heat shock proteins (Tandara et al., 2006

The effects of nutlin-3 were dose-dependent, with increasing concentrations of this inhibitor resulting in greater p53 stabilization, which correlated with increased induction of the p53 target genes CDKN1A and HDM2 and greater suppression of erastin2-induced ferroptosis (Fig S1AD)