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Butcher, A

The "minimal initial benefit" group (approximately 5-10% of users) reported limited improvements during treatment making discontinuation effects irrelevant, typically explained by inadequate product quality with degraded or low-concentration GHK-Cu, inappropriate application technique reducing absorption, unrealistic expectations exceeding what any topical can achieve, severe underlying pathology requiring medical intervention beyond cosmetic peptides, or individual non-responsiveness to copper peptide treatment for genetic or physiological reasons

The injectable versus oral comparison provides additional context on delivery method selection

& Cook, S

This is rare given the peptide occurs naturally in your body, but it happens

The finding shifted understanding of how mitochondria communicate beyond energy production, signaling through circulating peptides that reach distant tissues