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This unique immune profile supports enhanced antibody production and modulates neuroinflammation, a critical factor in AD pathology (Table 5) (Cacabelos, 2020)

[DOI] [PMC free article] [PubMed] 32.TZOULIS P, YAVROPOULOU M P BANCHEVA, et al

Lithium has also demonstrated antioxidant effects by increasing mRNA expression and protein levels of different glutathione S-transferase isoenzymes in rat cortical cells [95]

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Lipid metabolism: the central metabolic process in ferroptosis PUFAs, particularly arachidonic acid (AA)- and adrenic acid (AdA)-enriched phosphatidylethanolamines (PEs), serve as primary substrates for lipid peroxidation initiation, undergoing sequential enzymatic oxidation by long-chain acyl-CoA synthetase 4 (ACSL4), lysophosphatidylcholine acyltransferase 3 (LPCAT3), LOX, and Fe 2+ -mediated Fenton chemistry to generate phospholipid hydroperoxides (PLOOHs) [26]

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