glutathione menopause evidence Brain extended and closed forms levels decrease with age and extended glutathione is associated with visuospatial memory Glutathione deficiency induces epigenetic alterations

Storage Protocol Store lyophilized peptide at -20C in original packaging Reconstitute only the amount needed for current research phase Refrigerate reconstituted peptide at 2-8C Use within 4 weeks of reconstitution for BAC water preparations Document reconstitution date and concentration on vial Handling Practices Minimize Freeze-Thaw: Aliquot into single-use portions if freezing is necessary Aseptic Technique: Treat all reconstituted peptide as sterile

doi: 10.1146/annurev-immunol-032713-120245 82 DeshmukhHSLiuYMenkitiORMeiJDaiNOLearyCEet al

Methylation cycle hypothesis The methylation cycle hypothesis posits that a core component of the pathophysiology of chronic fatigue syndrome involves a partial block in the methylation cycle

Not all patients experience these side effects, but in those who do, both will go away shortly

The two peptides target complementary aspects of the aging process

Lou S, Lee HM, Qin H, Li JW, Gao Z, Liu X, Chan LL, Lam VKL, So WY, Wang Y, Lok S, Wang J, Ma RCW, Tsui SKW, Chan JCN, Chan TF, Yip KY (2014) Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation