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Tao Wang, [email protected] These authors have contributed equally to this work This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47

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However, certain cancer models are resistant to ferroptosis [75] and are characterized by an aggressive tumor type

Coloff (Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA) for helpful commentary and discussion