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Working with a healthcare provider who understands this relationship, you can calculate a personalized B12 approach based on your kidney function: normal function allows standard dosing, mild decrease might call for 75% of standard doses, moderate decrease might need 50% of standard, and severe decrease might require 25% of standard with closer monitoring

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Early research suggests that 5-Amino-1MQ works by reducing the activity of NNMT (nicotinamide N-methyltransferase), a naturally occurring enzyme found throughout the body that plays a crucial role in regulating cellular energy metabolism and fat storage within cells, as well as the rate at which your body burns through NAD+