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Owing to their high intracellular abundance, they also serve as indicators of compromised cellular integrity: once released extracellularly, HSP70s act as damage-associated molecular patterns (DAMPs), triggering immune responses through receptors such as the toll-like receptors TLR2 and TLR4 (Theivanthiran et al., 2022

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Iron activates NF-B in microglia which triggers the production of pro-inflammatory cytokines, including NO

Chronic low-dose aspirin therapy irreversibly inhibits the cyclooxygenase-1 ( COX-1) activity in platelets, leading to reduced thromboxane A2 production and thereby exerting anti-platelet aggregation effects

Research Applications The vast majority of research on BPC-157 has been conducted in preclinical settings using laboratory animals