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for IN delivery of nanoparticles to rats in part addressed this concern, with only 50100 L of a haloperidol-loaded NP suspension inducing a cataleptic response in rats and transport to the olfactory bulb and striatum at a higher concentration than with a pipette [88]

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doi: 10.1056/NEJMoa1714519 61 TanakaAHiroharaJNakanoTMatsumotoKChazouillresOTakikawaHet al

Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]

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