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In contrast, ALCAR shines in supporting brain energy metabolism, ensuring neurons function efficiently under stress or fatigue

doi: 10.1007/s00467-018-4157-2 97 NjeimRAlkhansaSFornoniA

-KG: alphaketoglutarate

Studies have shown that lactate can inhibit the polarization of M1 proinflammatory macrophages while promoting the polarization of M2 macrophages toward an anti-inflammatory and proangiogenic phenotype, with these effects being mediated through various mechanisms, including histone posttranslational modifications and signaling pathway regulation (107, 108)

Curcumin Curcumin, the active compound in turmeric, modulates HATs and HDACs, impacting gene expression linked to inflammation, cancer, and neurodegenerative diseases (Hassan et al