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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Burgos J., Viribay A., Calleja-gonzlez J., Fernndez-lzaro D., Olasagasti-ibargoien J., Seco-calvo J., Mielgo-ayuso J

The E3 ligase acts as a docking platform to attach the Ub-containing E2 enzyme to a particular substrate, enabling the Ub to bind to the lysine residue of the substrate protein

This perpetuates chronic inflammation preventing tissue repair

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Studies using this and related approaches, largely from Meisters group, established that adequate protein nutrition and specifically an adequate supply of sulfur amino acids is what keeps the glutathione system running