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This review provides an up-to-date and integrative overview of current evidence regarding ASTs mechanisms of action across experimental and preclinical models of neurodegenerative diseases such as Alzheimers, Parkinsons, and Huntingtons diseases

Tumors , cysts or abscesses Severe trauma such as severe fractures in the lumbar spine, or lacerations/stab wounds that causes complete nerve damage or a severed nerve

Low levels can cause: Tingling or numbness in hands and feet Difficulty walking or balance problems Muscle weakness Memory problems Poor concentration Mood changes (depression, irritability) Cognitive decline in severe cases Other B12 deficiency signs Sore or red tongue Mouth ulcers Vision disturbances Dizziness Cold hands and feet Causes of Vitamin B12 Deficiency Vitamin B12 deficiency happens either due to low intake or poor absorption

Its advisable to start with a lower dose and gradually increase if needed, always under the guidance of a healthcare professional

A switch to DOR may thus be an interesting treatment option where weight gain is a concern

Cyanocobalamin is the most commonly used form in supplements and fortified foods