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Extended protocols may be appropriate for individuals with significant body composition goals, those who respond gradually to therapy, or patients seeking comprehensive metabolic optimization under close medical supervision

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Kuldell N, Bernstein Ingram K, Hart K

However, it is best to avoid treatments consistently under 12 weeks when possible because there may be some risk of antibody formation against Botox which can make it less effective over time

Once the initial phase is complete, most patients transition to a maintenance plan that ranges from once every one to two weeks, or sometimes monthly, depending on individual response and wellness goals

The fluorescence images were obtained by Axio Observer (ZEISS, Oberkochen, Germany)