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Subsequently, GFRAL-GDF15 continued to activate the intracellular signaling pathways of AKT, ERK1/2, and phospholipase C (PLC), but not the SMAD pathway

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Multiplex pedigrees often include rare, highly penetrant mutations in CARD14, as well as common, less significant susceptibility alleles

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In particular, Th17 cell development is promoted by the buildup of glycolytic intermediates, which further activates transcription factors including RORt, Runx1, and Irf4 (67, 68)

doi: 10.1002/smll.202403560 109 ZhangYSAlemanJShinSRKilicTKimDShaeghSAMet al