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Increase in tetrahydrobiopterin release from PC12 cells under hypotonic culture conditions is inhibited by HgCl2

however, these models were less common

10.3390/ani11102944 80

Toxic metals exert their harmful effects through several common mechanisms, such as enzyme inhibition, disruption of subcellular organelles, and interaction with DNA, which can result in mutagenesis, apoptosis, or carcinogenesis ( Figure 1 )