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The amino acid driven alteration of diversity and composition of the GM can also be modulated by the different types of metabolites produced, including nitric oxide, ammonia, polyamines, hydrogen sulfide (H 2 S), indoles, and phenols in both the proximal and distal intestine (Dai et al., 2011

This variability in drug action within the unique CNS tumor microenvironment further complicates the therapeutic efficacy and predictability of these agents (110)

Role of Glutathione in Detoxification GSH is fundamental in neutralizing harmful endogenous and exogenous substances, including xenobiotics, reactive metabolites, and environmental toxins

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