interaction of chloroacetamide electrophiles with cellular glutathion NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation Discovery of novel benzylaniline derivatives

Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple negative breast cancer ScienceDirect Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development PMC Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C terminal Hydrolase L3 bioRxiv Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Cellular Exposure to Chloroacetanilide Herbicides Induces Distinct Protein Destabilization Profiles ScienceDirect Design, synthesis, and biological evaluation of nitroisoxazole containing spiro[pyrrolidin oxindole] derivatives as novel glutathione peroxidase 4 mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation ScienceDirect

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