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First, LCA is typically one of the most abundant bile acids in the human colon, and in our assays, it promoted biofilm formation by EcN at concentrations within the ranges reported for human feces and cecal contents

Further, it is also important to keep in mind that cancer cells can also acquire resistance to epigenetic therapies, which can then interfere with the expression of genes involved in cell cycle regulation, DNA repair, and apoptosis, making therapies become inefficient

[DOI] [PMC free article] [PubMed] [Google Scholar] Oja SS, Janaky R, Varga V, Saranasaari P

& Bollenbach, A

Salmani-Javan E, Jafari-Gharabaghlou D, Bonabi E, et al