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In most cases, numerous pathophysiological pathways can co-exist and may all negatively impact EF

A competitive binding assay was utilized to determine the K i of each compound similar to previous reports 55,56

Khiev D, Mohamed ZA, Vichare R, Paulson R, Bhatia S, Mohapatra S, et al

WildmanRPMuntnerPReynoldsKMcGinnAPRajpathakSWylie-RosettJet al

The Y-maze spontaneous alternation test, which can be used longitudinally to assess working memory in the same cohort of mice [89,90,91], was performed at 6, 15, and 21 months of age