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The subjects were divided into four treatment groups: [1] Control group (vehicle) Low-dose paraxanthine (equivalent to 25mg human dose) High-dose paraxanthine (equivalent to 100mg human dose) High-dose caffeine (equivalent to 100mg human dose) To assess cognitive function, the researchers employed the Morris water maze test , a well-established method for evaluating spatial learning and memory

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Like the binding mode for GSH, CP17 is bound within the VP1VP3 interprotomer pocket of the wt PV2 VLP through two critical arginine residuesArg243 and Arg258from neighbouring VP1 subunits, which form hydrogen bonds and salt-bridges with the carboxylate group of CP17 (Fig

doi: 10.1111/j.1365-2222.2010.03531.x 104 LarabiABMassonHLPBumlerAJ

Based on the function of Tregs and their ability to induce cytokine immunosuppression, researchers consider treating AR by increasing IL-10, TGF-, and IgG4 levels and Treg cell counts to induce immune tolerance [105]