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For anxiety with chronic disease (ACD), the removal of one article (Mojtahedi et al., 2024) resulted in a substantial reduction in heterogeneity, with the I 2 value decreasing from 84% to 0%, while the treatment effect remained statistically significant, changing from SMD -0.32 (95% CI: 0.50, 0.15) to SMD -0.22 (95% CI: 0.40, 0.05)

Hydroxocobalamin, in particular, is retained in the body longer than cyanocobalamin, which can reduce the frequency of repeat injections

The ADOS is a semi-structured assessment administered by a trained assessor that consists of various activities that allow the observation of social and communication behaviors related to the diagnosis of ASD (43)

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Other nutrients, such as B vitamins, vitamin C, vitamin E, selenium, and omega-3 fatty acids have also been shown to support glutathione levels, so eating foods that are high in these nutrients may also be helpful [14]

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