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For inflammatory bowel disease, mesalamine, corticosteroids, immunomodulators (azathioprine, methotrexate), and biologics (infliximab, adalimumab, vedolizumab, ustekinumab) all have Level 1 evidence from Phase III trials with thousands of patients

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Am J Pathol , 1995, 146(1): 56-66

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Some common signs include: Fatigue and weakness Numbness or tingling Memory issues Pale or yellowish skin Shortness of breath and dizziness Fast or irregular heartbeat It is time to take vitamin B12 to improve symptoms, depending on individual cases