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6.5 Clinical and translational evidence: limitations and prospects Although preclinical and pathological studies provide substantial support for the role of ferroptosis in Alzheimers disease, direct human evidence and clinical translational research remain significantly insufficient, representing a critical bottleneck in current investigations

This trial randomized 440 patients and demonstrated an improvement in overall survival for the S-1 group (adjusted HR 0.69, 95% CI 0.510.94) in the primary analysis