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Beyond BBB penetration, the selection of DDS in AD should also consider disease-specific pathological features that may affect therapeutic access and efficacy

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A key consideration of exosomes is that the challenges in extracting biological fluid-derived exosomes, for example, in plasma, where enrichment of biological molecules and various exosome species exists, thereby an issue like the corona effect occurs (Voke et al., 2025)

It uses a combination of mild cleansing agents (cetrimonium chloride, cetylpyridinium chloride, hexylene glycol, peg-6 caprylic/capric glycerides) and should be able to cleanse the skin gently

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