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While patients do often see a flare-up in acne breakouts when they first begin taking Accutane, these breakouts should clear up within the first few weeks of treatment, and patients will continue to see improvement throughout the time theyre taking isotretinoin

Tang S, Yang L, Tang X, Liu M

The area under ROC curve (AUROC) for LM2 to LM7 for 28-day mortality was 0.777, 0.771, 0.778, 0.791, 0.809, and 0.796 in consecutive order

The ketogenic diet increases ketone bodies such as beta-hydroxybutyrate, which provides an alternate energy source to neurons, thus offering neuroprotection and reduced neuroinflammation (146)

Clin Toxicol 1988;26:67-79

The result is the appearance of slowly increasing white patches, without any change in the skin texture