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The percentage of infants with vitamin B 12 deficiency was 26% in those born to supplemented mothers, which was significantly lower than the 31% to 37% reported in those not given a vitamin B 12 supplement

This may be due to the specific ability of periodic hypoxia to change the respiratory activity of neurons due to the induction of serotonergic-dependent long-term relief of respiratory activity (Turner and Mitchell, 1997), whereas prolonged hypoxia does not cause this alteration (Dwinell et al., 1997)

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Moreover it is still important to note, that many patients treated in young age, that we follow-up today in cardiology/oncology departments, received treatment based on chemotherapy only and still need to be monitored for cardiotoxicity