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People most at risk of deficiency include older adults, vegans, and those with specific medical conditions or taking certain medications

The MHRA are only recently catching up only for it to be ridiculed by some GPs and neurologists in 2022

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doi:10.1007/s11695-017-3102-y

111 Understanding how genetic and epigenetic, neurologic, hormonal, and immune mechanisms contribute to the experience of pain may help patients reconceptualize their condition, feel less anxious, and feel more empowered to make changes that can improve their outcomes