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However, a high-sugar diet for the first two-to-three weeks in adulthood showed a long-lasting effect on gene expression and lifespan, suggesting a memory of at least some components of the early adult diet in Drosophila 11

Dysbiosis-induced increased intestinal permeability allows the translocation of bacterial endotoxins, notably LPS, into the systemic circulation, triggering inflammatory cascades that compromise thyroid tissue integrity and hormone synthesis

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