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This anti-inflammatory effect was mechanistically linked to niacins ability to attenuate oxidative stress by inhibiting NADPH oxidase activity and reducing ROS production, a key driver of inflammatory signaling in NAFLD pathogenesis ( However, the anti-inflammatory role of VB3 is not universally observed across all experimental models, as evidenced by a controversial study by Further supporting a role for VB3, recent evidence continues to highlight the therapeutic potential of nicotinamide

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Meanwhile, their high stability and affinity for tumor cells enable them to carry drugs to tumor sites for therapeutic effects ( Although NDDS enhance drug efficacy through targeted delivery, microenvironment-responsive strategies, and multimodal synergies, their clinical translation remains challenging

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