foxo4 dri senolytic 2023 2024 foxo4-dri peptide human trial FOXO4-DRI UK The disordered p53 transactivation domain
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications FOXO4 DRI improves spermatogenesis in aged mice through reducing senescence associated secretory phenotype secretion from Leydig cells ScienceDirect A nutrigeroscience approach: Dietary macronutrients and cellular senescence: Cell Metabolism Senolytics: charting a new course or enhancing existing anti tumor therapies? Cellular Oncology Springer Nature Link Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv
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