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Immunological cues trigger biosynthesis of LTC 4 in mast cells by assembly of a biosynthetic complex at the nuclear envelope, consisting of cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO), 5-LO activating protein (FLAP) and LTC 4 synthase (LTC 4 S)

Investigational strategies for detection and intervention in early lung cancer

Human studies suggest that the dietary intake of 20 mg of niacin (or niacin equivalents) is enough to meet daily requirements [1]

TERT promoter mutation Mutations in the promoter region of the TERT gene have emerged as key molecular alterations in gliomas, influencing tumor progression, prognosis, and treatment response

Journal of Ethnopharmacology , 211 , 117125

9 Despite their structural similarity, each protein has unique activities and is expressed as multiple isoforms via alternative promoters or splicing