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Hormonal Treatments: Medications containing estrogen or synthetic hormones like diethylstilbestrol are well-known melasma triggers

Most reproductive processes, including gametogenesis, fertilization or embryonic development, can be influenced by extremely high environmental temperatures that directly impact reproductive performance 33,40,41

A low pH reversed-phase separation was conducted using a mass spectrometry grade solvent A (2% acetonitrile, 0.1% formic acid in 98% water) and solvent B (0.1% formic acid, 98% acetonitrile, 2% water) over a total duration of 185 min

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The main surprising element was that this patient was taking as much vitamin D as possible to strengthen the bones but was not aware that there was a risk of toxicity with extremely large doses