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Inhibition of GCS It is well known [27, 41] that GSH is a competitive inhibitor against glutamate of GCS, the enzyme that catalyzes the synthesis of glutamyl-cysteine

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As a cofactor for enzymatic reactions, it participates in DNA synthesis and repair, part of cellular maintenance

Theranostics 2018;8:23755

In the chondrocytes of the iron overload model, the levels of GPX4 and SLC7A11 within the antioxidant system were lower, whereas lipid peroxidation levels, indicated by 4-HNE, were higher, and their mitochondria exhibited characteristics similar to ferroptosis (175)

Reduced glutathione oxidizes rapidly in liquid form, losing 40% potency within 14 days even under refrigeration