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It is primarily researched for its interaction with nicotinamide N-methyltransferase (NNMT), an enzyme linked to energy balance and adipose tissue function

Endocrinologa y Nutricin (English Edition) 59(8):487490 Reinstatler L et al (2012) Association of biochemical B 12 deficiency with metformin therapy and vitamin B 12 supplements: the National Health and Nutrition Examination Survey, 19992006

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