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PMID: 35780904 Cell Tissue Res2022 Oct;390(1):93-112

Yang et al., 2022d

In the cytoplasm, Keap1 homodimer forms ubiquitin E3 ligase complex with cullin 3 (Cul3), which polyubiquitinates Nrf2 protein leading to its continuous proteasomal degradation ( Figure 3, right)