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This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

Organoids were harvested at day 7 (Matrigel) or day 4 (collagen), with both conditions collected at passage 2, each representing comparable growth stages for scRNA-seq analysis

Oxidative stress arises when there is an imbalance between oxidant generation and antioxidant capacity, leading to the accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), ultimately resulting in cellular injury and dysfunction 1

The BBB acts as an asset by securing the brain, however, on the other hand, there are certain challenges associated with it

After accounting for other factors, testosterone use was linked to a 34% lower death rate over the study period

Mohan R , Boukens BJ, Christoffels VM