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Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling

It also identifies many new candidate genes that affect steatosis that are future targets for MASLD therapy

Furthermore, new chemically synthesized compounds, such as BET inhibitors (BETi), have also shown promising potential in this regard

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In head-to-head trials against semaglutide, the most potent available GLP-1 receptor agonist, tirzepatide demonstrated meaningfully greater improvements in both glycemic control and weight reduction

Diabetologia 63 , 444447 (2020)