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Recent studies revealed that several agents inhibiting ACSL4 could protect against I/R injury

doi: 10.1155/2020/5394096 63 Lee-RueckertMEscola-GilJCKovanenPT

In other words, given the intricate molecular-level structure and function of the skin, it is evident that stimulating fibroblasts alone may prove insufficient for preventing or treating imperfections without an "integrated" approach