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Once anesthetized, the right knee joints of the animals were shaved, sterilized, and subjected to an intra-articular injection of collagenase type II

By stimulating collagen production and promoting wound healing, GHK topical treatments aim to improve skin texture, reduce the appearance of fine lines and wrinkles, and support skin regeneration

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The authors declare that this study received funding from Novo Nordisk

Initially constructed during the reign of Caliph Omar Ibn al-Khattab (634-644), the al-Haram Mosque has since undergone several renovations and has been expanded numerous times, notably in the eighth and fourteenth centuries