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Perraud et al., 2005), and nuclei through the sequential actions of nuclear enzyme poly-ADPR polymerase (PARP) and poly-ADPR glycohydrolase (PARG) in response to DNA damage and PARP stimulation (Esposito and Cuzzocrea, 2009

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Clinical translation of this co-delivery system faces challenges in scalability and biocompatibility validation

There is not yet a proposed mechanism for how antibiotic treatment affects tight junction expression in specific regions of the brain in these studies, but it could be through changes in metabolite composition or cytokine involvement