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Epigenomics 9(5):701710

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Although thioredoxin is not itself imported into the ER (being an 11.6 kDa protein rather than a small tripeptide like glutathione), the pathway has been shown to influence ER lumenal redox potential, likely through the conveyance of reducing equivalents through an as-yet unknown ER-resident transmembrane protein (Poet et al., 2017)

The beauty of this work is that the probe can be selectively activated in the liver at high specificity, Zheng said

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I dont believe for one moment that whats going on here is an honest investigation of whether these products should be compounded. Scott Brunner of the Alliance for Pharmacy Compounding said the coming meeting will be the start of a protracted process. Even if the panel votes to make the peptides available, and FDA agrees, the agency will still have to draft and publish rules on the change, he noted