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BMPs regulate NSC differentiation into astrocytes by acting through the phosphorylation of Smad proteins 1, 5, and 8, which combine with Smad4 in order to form a complex that translocates to the nucleus and regulates gene transcription (Itoh et al., 2000

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(2018) Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications Current Neuropharmacology, 16(5):505-516

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