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Some users wish for clearer guidance on combining it with other supplements for maximum effect

Vitamin B12 may be needed if youre pregnant or lactating, especially if youre also eating a plant-based diet, says Sue-Ellen Anderson-Haynes, MS, RDN, CDCES, owner of 360Girls&Women and spokesperson of the Academy of Nutrition and Dietetics

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Some of the negative effects of high homocysteine levels are modulated by the PON1 genotype.[ref] BLMH and BPHL are additional enzymes that can also metabolize homocysteine-thiolactone.[ref] Higher levels of homocysteine-thiolactone are also found in chronic inflammatory conditions, such as rheumatoid arthritis, inflammatory eye disease, and AMD.[ref][ref][ref] Lets take a look at why high homocysteine levels cause problems in the body, and then well look at genetic variants in the above cycles that can affect homocysteine levels when combined with dietary choices

Fagiani E, Christofori G

Hydrogen cross-feeders of the human gastrointestinal tract