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Epithelial Atg5 deficiency intensifies caspase-11 activation, fueling extracellular mtDNA release to activate CGAS-STING-NLRP3 axis in macrophages during Pseudomonas infection

The link between Kbhb of histones and hepatocellular carcinoma was also identified, and MTA2 interacts with HDAC2/CHD4 and represses BDH1 via R-loop transcription, leading to the accumulation of BHB and an increase in H3K9bhb, resulting in a cascade effect that promotes HCC formation and progression

[DOI] [PMC free article] [PubMed] [Google Scholar] 143

Nat Rev Urol 22 , 609631 (2025)

The study found that triglycerides cross the blood-brain barrier and can induce leptin resistance.[ref open access] Theoretically, it makes sense that high triglycerides would block the leptin signal in times of starvation, driving people to need more food

The blends anti-inflammatory and antioxidant mechanisms reduce oxidative stress and cytokine activity, improving the cellular environment for regeneration